Simon Patterson began his career in the music business with an A&R position, which he held for several labels. He was signed by Seb Fontaine and also worked for Judge Jules and supported both of them with the music selection for their weekly radio shows on BBC Radio 1.
He began playing as a DJ in 2000 and has been resident DJ at the Londoner Club The Cross. He also began producing music to make his name known. Simon Patterson became very popular through the trance project Dogzilla, which he ran from 2003 to 2008, along with Richie Kayvan. They had their biggest success with the single "Without You", which was ranked in some European charts.
In 2006, Simon Patterson released his first solo single "F-16". Two years later, he left the trance project Dogzilla to focus on his solo career.
In 2010, Patterson was ranked 28th in the annual "Top 100 DJs" vote by DJ Magazine.